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Early clinical observations in the 1880s suggested that tumor regression coincided with natural bacterial infections, leading to the first use of microbes as antitumor agents. With the development of the more effective and better understood radiation therapy, and later, chemotherapy-based cancer therapies this approach was largely abandoned in the 1930s and microbial-based therapy has remained an elusive goal. However, standard cancer therapies have several major disadvantages including rarity of complete and sustained remissions of most solid tumors, development of resistance and relapse and the frequent failure to clear micrometastases.

Oned 424 Avi 006 ((LINK))

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